Why This Study Matters

Monogenic diabetes is often underdiagnosed and frequently misclassified as type 1 or type 2 diabetes, leading to inappropriate treatment and missed opportunities for precision medicine. Many individuals with MODY (Maturity Onset Diabetes of the Young) remain unidentified due to lack of awareness, limited access to genetic testing, and absence of simple screening strategies in routine clinical practice. The UP-MDDI study aims to bridge this gap by developing a practical and clinically applicable approach for early identification of individuals at high risk for monogenic diabetes in the Indian population.

Objectives

• To identify clinical, biochemical, and family history features suggestive of monogenic diabetes.
• To develop and validate a simplified screening approach for detecting individuals at high risk for MODY.
• To improve awareness and recognition of monogenic diabetes among healthcare professionals.
• To facilitate timely referral for genetic testing and precision-based diabetes management.
• To study the clinical spectrum and phenotypic characteristics of MODY in the Indian population.

Expected Outcomes

• Early and improved identification of individuals with suspected monogenic diabetes.
• Reduction in misdiagnosis and inappropriate long-term insulin use.
• Better selection of patients for genetic testing.
• Improved personalized treatment strategies and clinical outcomes.
• Development of a practical screening framework that can be integrated into routine diabetes care settings across India.